Overexpression of circRNA itchy E3 ubiquitin protein ligase (circ-ITCH) can improve renal function in SA-AKI mice and regulate oxidative stress and mitochondrial dysfunction in sepsis-induced AKI through the miR-214-3p/ABCA1 pathway, further enriching the pathophysiology of SA-AKI (61). This evidence concerns the gene ABCA1 and acute kidney injury.