FAP and intrahepatic cholangiocarcinoma: After an earlier study demonstrated its potent affinity for human FAP protein and its effective binding in vitro (IC50 from 1.3 to 2.2 nM) (13, 14), it was suggested that [68Ga]Ga-FAP-2286 was superior to [18F]FDG for detecting lesions in selected cancers, such as gastric, pancreatic, and hepatic tumors (particularly intrahepatic cholangiocarcinomas) (15).