The results showed that the risk of progressing to MDR-TB was 8.23 times higher in those with CRP ≥ 37.3 mg/L than in those with CRP < 37.3 mg/L [Odds Ratio (OR) = 8.23, 95% confidence interval (CI): 6.36–10.64, p < 0.001]. Here, CRP is linked to multidrug-resistant tuberculosis.