Since depression is the most common neuropsychiatric disorder among PLWH (Abas et al., 2014) and is associated with negative HIV outcomes (i.e., poor adherence to antiretroviral therapy (ART), faster progression to AIDS, slower CD4 recovery) (Berhe et al., 2013; Memiah et al., 2014; Wroe et al., 2015) and reduced quality of life, integrating depression treatment into HIV care becomes critical (Abas et al., 2014). This evidence concerns the gene CD4 and major depressive disorder.