TOP2A and metastatic malignant neoplasm in the lymph nodes: Univariate Cox analysis identified TNM stage (p = 0.003), T (p = 0.040), lymph node metastasis (p = 0.012), VALSG stage (p < 0.001), and TOP2A expression (p = 0.001) as variables that were significantly related to overall survival (Figure 5A).