CASP3 and neoplasm: Immunohistochemistry (IHC) assay was analyzed to detect the expressions of Ki67, a biomarker for cell proliferation, and cleaved caspase 3 (CC3), a biomarker for apoptosis, within the xenograft tumors, and the results showed that knockdown of SLC7A11AR inhibited tumor growth, while promoted tumor cell apoptosis (Fig. 2q-s).