IECs-specific knockdown of Ahr led to the expansion of clonogenic progenitor cells in mice with mutations in adenomatous polyposis coli (APC) and Kras genes (ApcS580/+; KrasG12D/+) and promoted cell growth in the gut epithelium to increase cecum and colon cancer in mice 168. The gene discussed is AHR; the disease is malignant colon neoplasm.