The following functions of JDP2 might be involved in regulating the AHR-NRF2 gene battery to regulate the ROS balance: (i) regulation of expression of solute carrier family 7 member 11 (SLC7A11) through the AHR-NRF2 axis to regulate ferroptosis and cell death; (ii) control of cardiac remodeling and function; (iii) control of oncogenicity in T-cell lymphoma, which can lead to the development of cancer; (iv) control of in vivo bone homeostasis and host defense by regulating neutrophil differentiation; and (v) chromatin remodeling and epigenetic regulation of AHR, NRF2, and JDP2. Here, NFE2L2 is linked to cancer.