Conversely, Price et al. showed that JDP2 was responsible for increasing p53 transcription by decreasing the expression of murine double minute 2 protein in human H1299 non-small cell lung cancer (NSCLC) and MCF7 breast cancer cell lines, which mutated Ha-Ras/K-Ras and PI3K/AKT signaling, respectively 126. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.