The overexpression of N-α-acetyltransferase 10 in colorectal cancer and the histone acetyltransferase (males absent on the first; MOF =KAT8) in non-small cell lung cancer enhanced NRF2 acetylation and nuclear localization to induce the respective NRF2 target genes for cancer progression 70,71. The gene discussed is NFE2L2; the disease is cancer.