The overexpression of SBSPON can significantly counteract the growth promotion and the inhibition of apoptosis of HSPA5 overexpression on bladder cancer cells when treated with DDP and TM (Fig. 7D-E), while the overexpression of HSPA5 had the opposite effects on bladder cancer cells with overexpressed SBSPON (Fig. S7A). Here, SBSPON is linked to urinary bladder cancer.