NSDUH: National Survey on Drug Use and Health; VHD: valvular heart disease; FAERS: FDA Adverse Event Reporting System; ERK: extracellular signal-regulated kinase; MAPK: mitogen-activated protein kinase; MDMA: 3, 4-methylenedioxy-N-methamphetamine; TNF-α: tumor necrosis factor alpha; PBMC: peripheral blood mononuclear cell; DOI: 2,5-dimethoxy-4-iodoamphetamine; CDP: cyclodextrin polymer; SH: sarpogrelate hydrochloride; LSD: lysergic acid diethylamide. The gene discussed is TNF; the disease is heart valve disorder.