Based on the known interactions between the FGF–FGFR system versus the GNA14 system, as described by a previous study (Zou et al., 2019), we inferred the underlying signaling context that a loss of the GNA14–GPCR system might activate the FGF–FGFR system in filaggrinHigh melanomas, and FGF signaling could further counteract interferon signaling (Jinesh et al., 2020; Maddaluno et al., 2020) to disable the Th1 cytotoxic module (Bradley et al., 1996) (Figure–1G). Here, GNA14 is linked to melanoma.