FLG and ichthyosis: GSEA examination of differentially expressed genes between the filaggrinHigh and filaggrinLow groups confirmed the enrichment of RNAs related to clinically observed known human phenotypes driven by filaggrins, such as atopic dermatitis, alopecia, and ichthyosis, in addition to cell–cell contact structures, skin keratinization, and keratinocyte differentiation signatures (Figure 1E).