All these data, taken together show that a major change in FGF/FGFR versus GNA14/Th1 cytotoxic module gene expression underlies filaggrinHigh melanomas, which blends with allergic skin disease signatures, such as atopic dermatitis, alopecia, and ichthyosis, in addition to cell–cell contact, skin keratinization, and keratinocyte differentiation. This evidence concerns the gene GNA14 and ichthyosis.