In this study, we aimed to investigate the potential association of MEG3 gene polymorphisms with the risk for DN through genotyping five single-nucleotide polymorphisms (SNPs) of MEG3 gene (rs4081134, rs10144253, rs7158663, rs3087918, and rs11160608) between 712 DN patients and 820 controls (diabetic individuals without neuropathic conditions). Here, MEG3 is linked to liver dysplastic nodule.