In our study, humanized RBP4/TTR mice (mice with humanized transthyretin and retinol binding protein 4) and RBP4/TTRVal50Met mice (mice with hereditary transthyretin amyloidosis) were established and divided into three groups by different genotypes and treatment strategies. Here, RBP4 is linked to Familial transthyretin-related amyloidosis.