The Receiver operating characteristic (ROC curve) of the RRI, VFP, proBNP, SOFA score, ADHERE risk score, and GWTG-HF scores for AKI occurrence in Figure 2 showed that RRI has 68% sensitivity and 64% specificity to detect AKI with an AUC of 0.711, but VFP has better results compared to RRI and other prognostic scores, with 86.4% sensitivity and 69.2% specificity with an AUC of 0.822. The gene discussed is NPPB; the disease is acute kidney injury.