ALB and congenital secretory chloride diarrhea 1: In contrast, the liver ECV showed strong correlations with the Fibrosis-4 Index (r=0.653, p<0.001) and the Aminotransferase-to-Platelet Ratio Index (r=0.607, p<0.001), while spleen ECV correlated more strongly with the Child-Pugh score (r=0.719, p<0.001) and the Albumin-Bilirubin Index (r=0.742, p<0.001).<h4>Discussion</h4>Liver and splenic ECV can effectively reflect the dynamic progression of CLD and correlate well with non-invasive tests in these patients.<h4>Conclusion</h4>Spectral-CT liver and splenic ECV could serve as non-invasive imaging biomarkers for severity stratification.