The subgroup analysis revealed that high CD47 expression was related to poorer OS in digestive system tumors (HR = 1.74; 95% CI: 1.46–2.07; p < 0.00001), respiratory system tumors (HR = 1.43; 95% CI: 1.20–1.71; p < 0.0001) and other system tumors (HR = 1.89; 95% CI: 1.44–2.48; p < 0.00001), however, it is important to note the heterogeneity that exists within the subgroup of other system tumors. Here, CD47 is linked to digestive system neoplasm.