TWAS analysis, mapping the 13 proteins to 12 encoding genes, revealed a significant negative association between IGFBP‐7 gene expression and AF risk in the eQTLGen dataset (OR = 0.87, 95% CI: 0.81–0.93, p = 3.14 × 10−5), which contrasts with the plasma IGFBP‐7 levels reported in the included studies. This evidence concerns the gene IGFBP7 and atrial fibrillation.