Leveraging our finding of high HER2, CXCL13, and CCL20 expression in the NSCLC TME (Fig. 1), we designed HER2-CAR T cells that either singly expressed the orphan chemokine receptors CXCR5 or CCR6 or co-expressed both high-specificity orphan pairing receptors CXCR5 and CCR6 (Fig. 2A). Here, CCR6 is linked to non-small cell lung carcinoma.