Furthermore, in the colon cancer SW480 cells, DNMT3A appears to be recruited by the hypoxia-induced histone mark H3K36me3 to demethylate the HRE in the TWIST1 promoter, thus allowing HIF-1α binding and transcriptional activation of the promoter to initiate the EMT process. Here, HIF1A is linked to malignant colon neoplasm.