We found that CSRP2 expression significantly increased in both low-grade glioma (LGG) and GBM tissues when compared to normal tissues (Fig. 1A and Supplementary Fig. S2A), and CSRP2 expression was higher in GBM with advanced pathological grades than those with low pathological grades (Supplementary Fig. S2B, C). The gene discussed is CSRP2; the disease is central nervous system cancer.