BCAR1 and glioblastoma: In addition, it was found that in the highly aggressive human glioblastoma cell line U87-MG, knockdown of p130Cas resulted in the transformation of cells from an elongated mesenchymal morphology to a rounded amoeboid morphology, suggesting that p130Cas plays a role in the maintenance of polarized mesenchymal morphology in U87-MG cells [69].