For those whose treatment was escalated, the continued rise in CRP centiles could also reflect continued poor response to therapy, potentially due to factors such as unidentified antimicrobial resistance, inadequate antibiotic exposure at the site of infection, or, importantly, the lack of or delay in achieving adequate source control of the primary infection (e.g., drainage of an abscess, or removal of an infected medical device). The gene discussed is CRP; the disease is infection.