Using E/M (CD104highCD44high) and M (CD104low CD44high) subpopulations isolated from MDA-MB-468 and HCC1143 basal-like breast cancer cell lines, we uncovered an upregulation of TCF1 and FOXC2 in E/M relative to M cells, which was in turn able to convert M into E/M cells. The gene discussed is FOXC2; the disease is breast cancer.