Moreover, a significantly increased expression of the IFN-γ response gene set was detected in MPN patients with JAK2 mutations compared to MPN patients with CALR mutations in the gene set GSE174060, while in gene set GSE103176 only a trend of higher IFN-γ was found (Supplementary Fig. S3A–H). Here, CALR is linked to myeloproliferative neoplasm.