Noteworthy, the miR-223 expression was inversely correlated with its target genes, including glutamate ionotropic receptor NMDA-type subunit 2B (GRIN2B) and glutamate ionotropic receptor AMPA-type subunit 2 (GRIA2), suggesting its potential role in inhibiting glutamatergic signaling in psychiatric disorders [76]. This evidence concerns the gene GRIN2B and psychiatric disorder.