Next, we investigated the mechanism by which OFD1 regulates BRCA1 transcription, GSEA molecular signatures analysis in OFD1 knockdown pancreatic cancer cells revealed significant enrichment of genes regulated by the DREAM complex in both PANC1 and MIA PaCa-2 cells upon OFD1 knockdown (Fig. 5b, c). The gene discussed is BRCA1; the disease is familial pancreatic carcinoma.