KRAS and cancer: To investigate the role of OFD1 in the KRAS-driven spontaneous PDAC model, we generated a stable Ofd1 knockout cell line derived from KPC1199 cancer cells, originating from pancreatic tumors of KPC mice58, and reduced Brca1 mRNA expression was also observed in Ofd1-knockout KPC1199 cells (Supplementary Fig. 9b, , c).