To further investigate the assembly of the DREAM complex on the BRCA1 promoter, chromatin immunoprecipitation (ChIP) experiments revealed that OFD1 knockdown increased the recruitment of E2F4, RBL2, RBBP4, and LIN54 to the BRCA1 promoter in both PANC1 and MIA PaCa-2 pancreatic cancer cells (Fig. 5k, l). Here, E2F4 is linked to familial pancreatic carcinoma.