Additionally, PD-related mutations at the Roc-COR-Kinase-WD40 region, such as I2020T, L1795F, Y1699C, R1441C/H/G, A1442P, and G2385R, though positioned away from the direct LRRK2:14-3-32 interface, have been reported to disrupt 14-3-3 interactions23,94. The gene discussed is LRRK2; the disease is Parkinson disease.