VAPB WT interactome studies have been previously performed to help elucidate VAPB functions; however, they have not been carried out in a disease context, in comparison to mutant VAPB P56S, or in motor neurons, the main cell type affected in ALS (Cabukusta et al, 2020; James et al, 2019). The gene discussed is VAPB; the disease is amyotrophic lateral sclerosis.