Specific to HFRS, we additionally identified multiple colocalized signals in KHK and MET, while for HFRS without dementia, we identified additional colocalized signals in ADARB1 and PSMB7. Aside from a few links to blood pressure, plasma lipids or BMI in the GWAS Catalog, CHST9, CGREF1, PPP6C, KHK, MET, ADARB1 and PSMB7 have no prior GWAS associations with the HFRS conditions, suggesting that HFRS, as a composite measure, can offer insights into frailty beyond its individual components. Here, PPP6C is linked to dementia.