CGREF1, a gene linked to cell cycle regulation and adhesion20, and PPP6C, a gene involved in nuclear factor-κB pathway regulation21, showed the same sQTL-colocalized gene–tissue pairs for HFRS and HFRS without dementia, supporting their functional roles in frailty, irrespective of the HFRS definition. The gene discussed is PPP6C; the disease is dementia.