Significantly associated proteins at a false discovery rate (FDR) < 0.05 in both models 1 and 2 were CGREF1, MET, ALDH2, NECTIN2, APOC1, APOE and FOSB for HFRS, and CDK and POF1B for HFRS without dementia (Fig. 4 and Supplementary Table 10). The gene discussed is ALDH2; the disease is dementia.