The current study's results demonstrate that VWF Ag is a major indicator of liver fibrosis (P < 0.001), demonstrating strong diagnostic performance across all evaluated cutoff values (> 266.5 in mild fibrosis and > 590.3 in severe fibrosis) with 100% sensitivity, specificity ranging from 86.7% to 92.9%, PPV ranging from 85.7% to 88.2%, and NPV 100%. The gene discussed is VWF; the disease is fibrosis.