Coiled-coil-helix-coiled-coil-helix domain containing 2 (encoded by CHCHD2) forms a complex with CHCHD10, another nucleus-encoded mitochondrial protein of the CHCHD-containing protein family, known to be genetically linked to ALS and FTD73–75. The gene discussed is CHCHD2; the disease is amyotrophic lateral sclerosis.