TARDBP and amyotrophic lateral sclerosis: To determine whether the gene expression changes identified in our TDP-43 models resemble those dysregulated in other TARDBP mutant iPSC-derived MNs, we turned to a database by Ziff and colleagues49 (available from https://oliverziff.shinyapps.io/als_genome_instability/) which catalogs differential expression data generated from RNA-seq datasets of 429 ALS and control iPSC-derived MN lines.