Coiled-coil-helix-coiled-coil-helix domain containing 2 (encoded by CHCHD2) forms a complex with CHCHD10, another nucleus-encoded mitochondrial protein of the CHCHD-containing protein family, known to be genetically linked to ALS and FTD73–75. This evidence concerns the gene CHCHD10 and amyotrophic lateral sclerosis.