Abemaciclib also inhibits CDK2/Cyclin A/E and CDK1/Cyclin B. In addition to cell cycle blockade, CDK4/6i can also induce a senescence-like state, promote epigenetic remodelling, autophagy, blockade of oncogenic signalling networks and promote tumor immunogenicity9,10. The gene discussed is CDK4; the disease is neoplasm.