It is interesting to note that the rs121918009 variant in ALPL (c.1001G>A; p.Gly334Asp) (OMIM*171760; ICD‐11 5C64.3) found in SBM with an allele frequency of 1.69% (Table 2), and associated with hypophosphatasia, has been reported in the Canadian Mennonite population in patients with hypophosphatasia, described as p.Gly317Asp (the same codon but after discounting the signal peptide) [26]. The gene discussed is ALPL; the disease is hypophosphatasia.