In a study depicting the role of IKKα and IKKβ in KRAS-mutant lung adenocarcinoma, IKKα enhanced both genetic and chemical KRAS-mutant lung adenocarcinoma, and high IKKα expression was observed in cells from urethane-treated FVB and Ad-Cre-treated LSL.KRASG12D (KRAS mutation) lung adenocarcinoma mice models [55]. The gene discussed is KRAS; the disease is lung adenocarcinoma.