Notably, most of these DEGs were upregulated in Mx1-CreCbfb+/56M and Mx1-CreCbfb+/56M-ΔHABD mice (clusters c4, c5, and c6 compared with clusters c1, c2, and c3), consistent with our previous finding that the transcriptional activation role of CBFβ-SMMHC is more prominent in Cbfb-MYH11–induced leukemia (18). Here, CBFB is linked to leukemia.