Furthermore, SMMHC binding enrichment at TSSs was lower in Mx1-CreCbfb+/56M-ΔHABD cells compared with Mx1-CreCbfb+/56M cells, which may have contributed to delayed leukemia development in Mx1-CreCbfb+/56M-ΔHABD mice. The gene discussed is MX1; the disease is leukemia.