RUNX1 and leukemia: Interestingly, upregulated DEGs in Runx1+/R188QMx1-CreCbfb+/56M cells positively correlated with CHYLA_CBFA2T3_TARGETS_DN and negatively correlated with CHYLA_CBFA2T3_TARGETS_UP, suggesting a critical role for CBFA2T3 that may contribute to the loss of leukemia initiation ability in Runx1+/R188QMx1-CreCbfb+/56M mice.