Additionally, the upregulated DEGs in Mx1-CreCbfb+/56M cells also positively correlated with CHYLA_CBFA2T3_TARGETS_UP and negatively correlated with CHYLA_CBFA2T3_TARGETS_DN, suggesting a critical role for CBFA2T3 during leukemia initiation in Mx1-CreCbfb+/56M mice. The gene discussed is CBFA2T3; the disease is leukemia.