RUNX1 and leukemia: Importantly, we were able to demonstrate that the clusters (c1 and c2) with the highest expression levels of leukemia-related genes were markedly reduced in the Runx1+/R188QMx1-CreCbfb+/56M mice, with a corresponding increase of cluster c0, which appeared to be less advanced in leukemogenesis in the pseudotime trajectory plot and to have lower expression levels of the leukemia genes.