We found that the binding affinity between RHD and its target DNA oligonucleotide was significantly enhanced in the presence of CBFβ-SMMHC and CBFβ-SMMHC-ΔHABD (which can induce leukemia), but not of CBFβ-SMMHC-mDE (which cannot induce leukemia) (Figure 2, A and B). This evidence concerns the gene RHD and leukemia.