Annotated genes in the TGF-β signaling (TGF-β) pathway and Gonadotropin-releasing hormone receptor (GRHR) pathways are highly overlapped (Fig 1A), as are genes in the Cadherin signaling (CADH) and Alzheimer’s disease presenilin(ALZ) pathways (Fig 1B). The gene discussed is GNRHR; the disease is glycogen storage disease VI.