However, of those genes included in the pPRS score, prior evidence links NSAIDs anti-cancer activity with β-catenin (CTNNB1 [40–43]), GNAS [44], and PTGER4 [19], the extracellular receptor for PGE2 that is the major downstream prostanoid produced by PTGS-2. The gene discussed is PTGER4; the disease is cancer.