Annotated genes in the TGF-β signaling (TGF-β) pathway and Gonadotropin-releasing hormone receptor (GRHR) pathways are highly overlapped (Fig 1A), as are genes in the Cadherin signaling (CADH) and Alzheimer’s disease presenilin(ALZ) pathways (Fig 1B). Here, TGFB1 is linked to glycogen storage disease VI.