Metabolic and cardiovascular disorders, such as hypertension, obesity, diabetes, gut dysbiosis, chronic kidney disease and sepsis, are known to stimulate the activation of nucleotide‐binding oligomerization domain‐like receptor protein 3 (NLRP3).173, 174, 175, 176, 177, 178, 179, 180. The gene discussed is NLRP3; the disease is hypertensive disorder.