In contrast to increased susceptibility to infection induced by suboptimal activity of IFNγ, patients with IFNγ overproduction exhibit typical hyperinflammatory disorders, such as lupus erythematodes and hemophagocytic lymphohistiocytosis (HLH), including macrophage activation syndrome [13], the latter reflecting a rare but well defined endotype of sepsis. This evidence concerns the gene IFNG and macrophage activation syndrome.