GLP1R and Hyperglycemia: To confirm that metabolic stress associated with hyperglycemia does not interfere with the efficacy or selectivity of the GLP1-Sirt2 ASO, we analyzed tissue Sirt2 and Glp1r expression levels in mice that were treated with the GLP1-Sirt2 ASO for 3 weeks and subsequently rendered acutely hyperglycemic by S961 (Figure 5D).