MMP8 and periodontitis, aggressive: For instance, research has shown that in the Taiwanese population, hypertensive individuals carrying the MMP-8 rs11225395 CT or TT genotype have a higher risk of RCC compared to those with the wild-type CC genotype.19 Furthermore, the T allele and T allele genotypes (CT, TT) are more frequently observed in generalised aggressive periodontitis (GAgP) cases; compared to the wild C allele and CC genotype, the risk of GAgP is 6.76 times higher.10 In summary, our study confirmed that the MMP-8 rs11225395 SNP is statistically significantly associated with PI.