Specifically, among Taiwanese individuals with hypertension, those carrying the MMP-8 rs11225395 CT or TT genotype exhibit a higher risk of renal cell carcinoma (RCC) compared to those with the wild-type CC genotype.19 Additionally, the MMP-8 rs11225395 SNP is identified as a risk factor for diabetic cardiomyopathy (DC).25 However, the mechanisms underlying the role of the MMP-8 rs11225395 gene polymorphism in the pathogenesis of PI remain unclear. This evidence concerns the gene MMP8 and hypertensive disorder.