In LSCC, stability of PLAU is regulated by a m6A methyltransferase WTAP resulting in cancer progression.20 As same as IGF2BP2, PLAU can also promotes cell proliferation and EMT in HNSCC that PLAU silencing inhibits the migration of OSCC Stage 4. The gene discussed is IGF2BP2; the disease is head and neck squamous cell carcinoma.