CEP55 (centrosomal protein 55) is essential for cell division and cytokinesis, playing a key role in regulating centrosome dynamics and cell cycle progression.17 It is often expressed lowly in most normal human tissues.7 Its overexpression causes genomic instability, which is a characteristic of cancer, such as breast cancer,14 oesophageal squamous cell carcinoma,42 etc. High expression level of CEP55 is related to poor prognosis of OSCC patients, independent of pathological stages or grades (32 as our risk score). The gene discussed is CEP55; the disease is cancer.