CCND3 and neoplasm: The tumor also demonstrated amplification of CCND3 (17 copies), a low tumor mutational burden (TMB) of 1.9 mutations/Mb, a microsatellite stable (MSS) phenotype, and massive whole-chromosomal losses with LOH involving chromosomes 1, 2, 3, 6, 8, 9, 10, 11, 12, 13, 15, 17, 18, and 22 (Fig. 1a), consistent with a near-haploid genome.