According to the Aβ cascade hypothesis, the excessive production of Aβ disrupts normal cellular functions, leading to synaptic dysfunction, neurodegeneration, tau hyperphosphorylation, and neuroinflammation, which ultimately result in memory impairment in individuals with AD and dementia (Leng and Edison, 2021; De Strooper and Karran, 2016). This evidence concerns the gene MAPT and Alzheimer disease.