Aβ peptides are derived from the sequential cleavage of amyloid precursor protein (APP) by β-secretase (β-site APP cleaving enzyme 1, BACE1) and γ-secretase, thus making this cleavage process significant in AD pathology (Tomita, 2014; LaFerla et al., 2007). This evidence concerns the gene BACE1 and Alzheimer disease.