S100A8 and adenocarcinoma: An important and initially unexpected advance came when Peek and Blaser began to explore whether cagA+ strains were associated with any of the increasingly prevalent conditions affecting the esophagus: reflux esophagitis (also called GERD), Barrett’s esophagus, and adenocarcinomas arising in the proximal stomach or distal esophagus (called GE junction adenocarcinomas).