Nuclear receptor subfamily 4 group A member 3 (NR4A3), a member of the nuclear receptor superfamily members, also referred to as Nor-1.14 It acts as an inhibitor in various tumors, such as lung cancer, liver cancer, leukemia, neuroblastoma and other tumors by triggering cell apoptosis.15–18 Studies have indicated that NR4A3, as a tumor suppressor gene in BLCA, restrains the growth and metastasis of BLCA by regulating EMT.19 Therefore, we assuming that NR4A3 might be enrolled in the regulation of anoikis resistance in BLCA. This evidence concerns the gene NR4A3 and bladder transitional cell carcinoma.