After the nude mice were killed and dissected, it was found that the overexpression of NR4A3 reduced the number of pulmonary tumor (p < .05, Figure 4d), and the HE staining of lung tissues also confirmed that the overexpression of NR4A3 reduced the lung metastasis of BLCA (Figure 4e). The gene discussed is NR4A3; the disease is bladder transitional cell carcinoma.