EWSR1 and sarcoma: EWSR1 (Ewing sarcoma breakpoint region 1) is an RNA-binding protein that, when fused with transcription factors like FLI1, forms oncogenic fusion proteins implicated in various sarcomas.21 Ezrin, a member of the ERM (Ezrin-Radixin-Moesin) family, functions as a membrane-cytoskeleton linker and is involved in cell shape, adhesion, and motility.