Subsequent GO and KEGG analyses further corroborated that PGC may influence Th17 cell differentiation and several signaling pathways, including the IL‐17, adipocytokine, TNF, and NF‐κB signaling pathways, thereby contributing to the amelioration of acne, atopic dermatitis, and skin barrier impairment. The gene discussed is NFKB1; the disease is acne.