DICER1 and type 2 diabetes mellitus: microRNA profiling studies have revealed that type 2 diabetes (T2DM) is associated with decreased levels of several platelet microRNAs4–6 and, in particular, microRNA-223, with consequently increased expression of platelet P2RY12 mRNA and P2Y12 protein contributing to platelet hyperreactivity.7,8 Dicer1 is reduced in diabetic platelets due to its cleavage by calpain, which is hyperactivated in diabetes.9