P2RY12 and diabetes mellitus: We found that a derangement of this self-regulatory mechanism occurs in diabetes, probably contributing to the platelet hyperreactivity and in vivo activation typical of these patients.35,36 In fact, although thrombin triggered microRNA-223 maturation also in T2DM platelets, this phenomenon was short-lasting, and P2RY12 mRNA rapidly returned to normal compared with healthy control platelets, leading to a premature restoration of receptor levels and function, possibly facilitating platelet hyperresponsiveness to ADP.