P2RY12 and pulmonary embolism: To check whether Dicer1-mediated downregulation of P2Y12 expression may reduce platelet reactivity and, thus, prevent thrombus formation, we triggered pulmonary embolism using a mix of 2-methylthioadenosine 5′-diphosphate and epinephrine in mice pretreated with a sublethal dose of thrombin, and we, indeed, observed a strikingly reduced mortality compared with mice pretreated with saline (Figure 6A and 6C).