IL10 and Splenomegaly: A correlation analysis of the most abundant fecal bacteria with cecal metabolites demonstrated positive correlations between P. distasonis and the abundance of UMP, N-acetyl leucine, and solanidine (Figure 5C), which are closely linked to the absence of Bank1. On the contrary, these same metabolites showed a negative correlation with splenomegaly and serum levels of IgG2c anti-dsDNA antibody levels, and a positive correlation with the abundance of IL-10-producing B cells from the Peyer’s patches (Figure 5D).