CCND1 and cancer: Subsequently, by studying the mechanism of action of HLB-apt on A549 and HepG2 cells, we discovered the mRNA expression of genes involved in cancer cell apoptosis, including BID, TP53, BIM, BAK1, BAX, AKT, CCND1, AKT, and BCL-2. Compared with the control group, the three apoptosis related genes BAK1, BIM, and BAX in A549 and HepG2 cells treated with HLB-apt were all expressed at significantly higher mRNA levels (P<0.01) (Figures 4C, D).