Surprisingly, leukemic blasts were completely depleted 14 days after CD19 CAR-T cell infusion, including CD19-positive tumor cells (Figures 1B, D), and the levels of RUNX1::RUNX1T1 fusion gene decreased from 327.64% to 144.82% (Table 2, Figure 1E). Here, RUNX1 is linked to neoplasm.