In this study, we identified several Tier 1 sepGIKs that exhibit differential expression between high- and low-activity immune cells in sepsis (FDR < 0.05; Figure 6B; Supplementary Table S16), including ZAP70 (zeta-chain-associated protein kinase 70), CX3CR1, FPR1, MCOLN1, NME4, C3AR1, PTGIR (prostaglandin I2 receptor), PTK2B (Protein Tyrosine Kinase 2 beta), and BLK. The gene discussed is C3AR1; the disease is Sepsis.