By inspecting metabolite profiles and their abundances (Supplementary Table S4), we found that D-glucose 6-phosphate displayed a remarkable accumulation in B. pseudocatenulatum (log2FC = 12.66), with its 1st sepGIK identified as pyruvate kinase (PKM; Supplementary Figure S7), a key regulatory enzyme in glycolysis and a promising target for sepsis intervention (10). The gene discussed is PKM; the disease is Sepsis.