Tier 2 sepGIKs included 89 sepGIKs (399 pairs), such as FFAR2 (free fatty acid receptor 2), CCR7 (C-C chemokine receptor type 7), HK3 (hexokinase 3), and IRAK3 (interleukin-1 receptor-associated kinase 3), which were differentially expressed in at least 14 sepsis datasets (Supplementary Table S11). Here, HK3 is linked to Sepsis.