The results suggested a poor OS in patients with GBM with low AIM2, CASP4, IL1B, NLRC4, NOD2, and PYCARD expression and high PLCG1 and SCAF11 expression (Supplementary Figure 1A), as well as a poor PFS with low AIM2, CASP4, GPX4, GSDMC, IL1B, NLRC4, NLRP3, NOD2, and PYCARD expression and high PLCG1 expression (Supplementary Figure 1B). This evidence concerns the gene GPX4 and glioblastoma.