We firstly screened pyroptosis-related genes with significant prognostic value in GBM by univariate Cox regression analysis of OS and found a poor OS in patients with GBM with low AIM2, CASP4, IL1B, NLRC4, NOD2, and PYCARD expression and high PLCG1 and SCAF11 expression. This evidence concerns the gene PLCG1 and glioblastoma.